Episode #475 from 41:17

Simulating a biological organism

So to go to your dream of modeling a cell, what are the big challenges that lay ahead for us to make that happen? We should maybe highlight that in AlphaFold, I mean there's just so many leaps. So AlphaFold solved, if it's fair to say, protein folding. And there's so many incredible things we could talk about there, including the open sourcing, everything you've released AlphaFold 3 is doing protein, RNA, DNA interactions, which is super complicated and fascinating. It's amenable to modeling. AlphaGenome predicts how small genetic changes if we think about single mutations, how they link to actual function. So it seems like it's creeping along to sophisticated to much more complicated things like a cell. But a cell has a lot of really complicated components. So what I've tried to do throughout my career is I have these really grand dreams and then I try to, as you've noticed, but I try to break them down. It's easy to have a kind of crazily ambitious dream, but the trick is how do you break it down into manageable, achievable, interim steps that are meaningful and useful in their own right? And so Virtual Cell, which is what I call the project of modeling a cell, I've had this idea of wanting to do that for maybe more like 25 years.

Why this moment matters

So to go to your dream of modeling a cell, what are the big challenges that lay ahead for us to make that happen? We should maybe highlight that in AlphaFold, I mean there's just so many leaps. So AlphaFold solved, if it's fair to say, protein folding. And there's so many incredible things we could talk about there, including the open sourcing, everything you've released AlphaFold 3 is doing protein, RNA, DNA interactions, which is super complicated and fascinating. It's amenable to modeling. AlphaGenome predicts how small genetic changes if we think about single mutations, how they link to actual function. So it seems like it's creeping along to sophisticated to much more complicated things like a cell. But a cell has a lot of really complicated components. So what I've tried to do throughout my career is I have these really grand dreams and then I try to, as you've noticed, but I try to break them down. It's easy to have a kind of crazily ambitious dream, but the trick is how do you break it down into manageable, achievable, interim steps that are meaningful and useful in their own right? And so Virtual Cell, which is what I call the project of modeling a cell, I've had this idea of wanting to do that for maybe more like 25 years.

Starts at 41:17
People and topics
All moments
Simulating a biological organism chapter timestamp | Demis Hassabis: Future of AI, Simulating Reality, Physics and Video Games | EpisodeIndex